Synthetic biology has the potential to provide solutions for the challenges of modern society and pave new ways to understand life. Our ability to design biological systems by synthetic biology is dependent on how to regulate gene expression. At Jang Laboratory, we integrate rational design and artificial evolution to create novel gene regulation systems for understanding fundamental biological processes and engineering valuable phenotypes. Particularly, we focus on nucleic acids that offer new opportunities for developing artificial gene regulators based on their programmability, versatility, low genetic footprint, and economic production both in vivo and in vitro.​ Using artificial gene regulators, we engineer microorganisms for improving energy, environment, and human health.

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Keywords: Synthetic Biology; Artificial Evolution; SELEX; Biosensor; Genetic Circuit; Artificial Intelligence

Applications: Microbiome-based Therapeutics; Gene therapy; Molecular diagnosis; Metabolic Engineering; Bioplastic; Enzyme and Protein Engineering

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키워드: 합성생물학; 실험실 진화; SELEX; 바이오센서; 유전자회로; 인공지능

용용분야: 마이크로바이옴 치료제; 유전자 치료제; 분자진단; 대사공학; 바이오플라스틱; 효소 및 단백질공학